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PRI 724

Drug Profile

PRI 724

Alternative Names: ICG-001; OP-724; PRI-724

Latest Information Update: 11 Nov 2019

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At a glance

  • Originator PRISM BioLab; University of Southern California
  • Developer Ohara Pharmaceutical; PRISM Pharma Co; Syneos Health; Tokyo Metropolitan Komagome Hospital
  • Class Antifibrotics; Antineoplastics; Small molecules
  • Mechanism of Action Beta catenin inhibitors; CREB-binding protein inhibitors; Wnt signalling pathway inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Primary biliary cirrhosis
  • Discontinued Acute myeloid leukaemia; Chronic myeloid leukaemia; Hepatic fibrosis; Pancreatic cancer; Solid tumours

Most Recent Events

  • 29 Aug 2019 Phase-I clinical trials in Primary biliary cirrhosis in Japan (IV) (NCT04047160)
  • 06 Aug 2019 Ohara Pharmaceutical and Japan Agency for Medical Research and Development plan a phase I trial in Primary biliary cirrhosis in August 2019 (IV) (NCT04047160)
  • 29 Aug 2018 Chemical structure information added
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