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Crizanlizumab - Novartis

Drug Profile

Crizanlizumab - Novartis

Alternative Names: ADAKVEO; Adakveo; Crizanlizumab-tmca - Novartis; SEG-101; Sel G1

Latest Information Update: 15 Jun 2021

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At a glance

  • Originator Selexys Pharmaceuticals
  • Developer Novartis
  • Class Antivirals; Monoclonal antibodies
  • Mechanism of Action P selectin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Sickle cell anaemia; Vaso-occlusive crisis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Vaso-occlusive crisis
  • Phase II Priapism; Vascular disorders
  • Phase I/II Myelofibrosis

Most Recent Events

  • 02 Jun 2021 Novartis suspends enrolment in the phase II SOLACE-kids trial for Vaso-occlusive crisis related to sickle cell anaemia (In infants, In children, In adolescents) in Belgium, Brazil, Canada, Colombia, France, Germany, India, Italy, Lebanon, Oman, Spain, Switzerland, Turkey, United Kingdom and USA (IV) (NCT03474965)
  • 19 May 2021 Novartis re-initiates enrolment in the phase II SOLACE-kids trial for Vaso-occlusive crisis related to sickle cell anaemia (In infants, In children, In adolescents) in Belgium, Brazil, Canada, Colombia, France, Germany, India, Italy, Lebanon, Oman, Spain, Switzerland, Turkey, United Kingdom and USA (IV) (NCT03474965)
  • 07 May 2021 Novartis suspends enrolment in its phase II SOLACE-kids trial for Vaso-occlusive crisis related to sickle cell anaemia (In infants, In children, In adolescents) in the US, Belgium, Brazil, Canada, Colombia, France, Germany, India, Italy, Lebanon, Oman, Spain, Switzerland, Turkey and the UK (IV) (NCT03474965)
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