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Polatuzumab vedotin - Genentech

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Drug Profile

Polatuzumab vedotin - Genentech

Alternative Names: ADC DCDS4501A; anti-CD79b-VC-MMAE; Antibody-Drug Conjugate DCDS4501A; DCDS-4501A; FCU-2711; polatuzumab vedotin-piic; polatuzumab vedotin-piiq; Polivy; RG-7596; RO-5541077; RO-5541077-000

Latest Information Update: 11 Dec 2024

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At a glance

  • Originator Genentech
  • Developer Chugai Pharmaceutical; Genentech; Roche; Weill Cornell Medical College
  • Class Antineoplastics; Auristatins; Drug conjugates; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; Mitosis inhibitors; Tubulin inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Diffuse large B cell lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Diffuse large B cell lymphoma
  • Phase III Follicular lymphoma
  • Phase II Chronic lymphocytic leukaemia; Non-Hodgkin's lymphoma; Richter's syndrome

Most Recent Events

  • 08 Dec 2024 Adverse event and efficacy data rom the phase III POLARIX trial in Diffuse large B cell lymphoma released by Genentech
  • 07 Dec 2024 Efficacy and adverse event data from a phase I trial in Diffuse large B cell lymphoma presented at the 66th American Society of Hematology Annual Meeting and Exposition 2024 (ASH-Hem-2024)
  • 29 Nov 2024 Hoffmann-La Roche completes a phase III POLARGO clinical trials in Diffuse large B cell lymphoma (Combination therapy, Second-line therapy or greater) US, Germany, Spain, Ireland and the UK, Brazil, Canada, China, Finland, France, Greece, India, Italy, South Korea, Mexico, Sweden, Turkey (IV) (NCT04182204) (EudraCT2018-003727-10)

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