Polatuzumab vedotin - Genentech

Drug Profile

Polatuzumab vedotin - Genentech

Alternative Names: anti-CD79b-VC-MMAE; DCDS-4501A; FCU-2711; RG-7596; RO-5541077; RO-5541077-000

Latest Information Update: 10 Aug 2018

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At a glance

  • Originator Genentech
  • Developer Chugai Pharmaceutical; Genentech
  • Class Antineoplastics; Auristatins; Drug conjugates; Immunoconjugates; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; Mitosis inhibitors; Tubulin inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Diffuse large B cell lymphoma
  • Phase II Non-Hodgkin's lymphoma
  • Phase I/II Follicular lymphoma
  • No development reported Chronic lymphocytic leukaemia

Most Recent Events

  • 01 Aug 2018 Chugai Pharmaceutical plans a phase II trial for Diffuse large B-cell lymphoma (Combination therapy, Recurrent, Second-line therapy) in Japan (JapicCTI184048)
  • 01 Jun 2018 Efficacy and safety data from a phase I/II trial in Diffuse large B-cell lymphoma presented at the 54th Annual Meeting of the American Society of Clinical Oncology (ASCO-2018)
  • 21 Apr 2018 Pharmacodynamics data from a preclinical study in Diffuse large B cell lymphoma presented at the 109th Annual Meeting of the American Association for Cancer Research (AACR-2018)
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