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Enfortumab vedotin - Astellas Pharma/Pfizer

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Drug Profile

Enfortumab vedotin - Astellas Pharma/Pfizer

Alternative Names: AGS-22C3; AGS-22CE; AGS-22M6E; AGS-22ME; AGS-M6; ASG-22CE; ASG-22M6E; ASG-22ME; Enfortumab; Enfortumab vedotin-ejfv; PADCEV

Latest Information Update: 17 Feb 2025

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At a glance

  • Originator Agensys; Seattle Genetics
  • Developer Astellas Pharma; Astellas Pharma Global Development; Merck & Co; Seagen
  • Class Antineoplastics; Auristatins; Drug conjugates; Immunoconjugates; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; Mitosis inhibitors; Tubulin inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Urogenital cancer
  • Phase III Bladder cancer
  • Phase II Solid tumours

Most Recent Events

  • 10 Feb 2025 Updated long term efficacy data from the phase-III EV-302 trial in Urogenital cancer released by Pfizer
  • 08 Jan 2025 Registered for Urogenital cancer (Combination therapy, First-line therapy, Late-stage disease, Metastatic disease) in China (IV)
  • 28 Nov 2024 No recent reports of development identified for phase-I development in Bladder-cancer(Second-line therapy or greater) in USA (Intravesicular)

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