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Research programme: monoclonal antibody therapeutics - Agenus

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Drug Profile

Research programme: monoclonal antibody therapeutics - Agenus

Alternative Names: AGEN 2041; Checkpoint modulator antibodies - 4-Antibody/Ludwig Institute for Cancer Research; Checkpoint modulator antibodies - Agenus/Incyte; CPM antibodies - Agenus/Incyte; Cytotoxic T-lymphocyte antigen 4 inhibitor antibodies - Agenus/Recepta; PDCD 1 protein inhibitor antibodies - Agenus/Recepta

Latest Information Update: 25 Feb 2026

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At a glance

  • Originator 4-Antibody; Ludwig Institute for Cancer Research
  • Developer Incyte Corporation
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Cytotoxic T-lymphocyte antigen 4 inhibitors; HAVCR2 protein inhibitors; OX40 receptor agonists; Programmed cell death 1 receptor antagonists; TNFRSF18 protein stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • No development reported Solid tumours

Most Recent Events

  • 17 Feb 2026 Incyte Corporation terminates licensing agreement with Agenus
  • 31 Oct 2022 Incyte Corporation intend to terminates its licence for OX40 program from October 2023
  • 28 Sep 2022 No recent reports of development identified for preclinical development in Solid-tumours in USA

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