Research programme: monoclonal antibody therapeutics - Agenus

Drug Profile

Research programme: monoclonal antibody therapeutics - Agenus

Alternative Names: AGEN 2041; Checkpoint modulator antibodies - 4-Antibody/Ludwig Institute for Cancer Research; Checkpoint modulator antibodies - Agenus/Incyte; CPM antibodies - Agenus/Incyte; Cytotoxic T-lymphocyte antigen 4 inhibitor antibodies - Agenus/Recepta; INCAGN-2390; INCAGN02390; PDCD 1 protein inhibitor antibodies - Agenus/Recepta

Latest Information Update: 08 Aug 2018

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At a glance

  • Originator 4-Antibody; Ludwig Institute for Cancer Research
  • Developer Incyte Corporation
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Cytotoxic T-lymphocyte antigen 4 inhibitors; HAVCR2 protein inhibitors; OX40 receptor agonists; Programmed cell death-1 receptor antagonists; TNFRSF18 protein stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Solid tumours

Most Recent Events

  • 01 Aug 2018 Preclinical trials in Solid tumours in USA (unspecified route) (Incyte Corporation pipeline, August 2018)
  • 21 Apr 2018 Pharmacodynamics data from a preclinical trial in Cancer presented at the 109th Annual Meeting of the American Association for Cancer Research (AACR-2018)
  • 01 Mar 2018 Agenus has issued and pending patents for SECANT® platform in USA
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