Drug Profile

Abemaciclib - Eli Lilly and Company

Alternative Names: Abemaciclib mesylate; Bemaciclib; Bemaciclib mesylate; LY 2835219; Verzenio; Verzenios

Latest Information Update: 28 Oct 2025

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At a glance

Originator Eli Lilly and Company
Developer Boehringer Ingelheim; Dana-Farber Cancer Institute; Eli Lilly; Eli Lilly and Company; Jules Bordet Institute; M. D. Anderson Cancer Center; Memorial Sloan-Kettering Cancer Center; Merck Sharp & Dohme; National Cancer Institute (USA); UCLAs Jonsson Comprehensive Cancer Center; Washington University School of Medicine
Class Aminopyridines; Antineoplastics; Benzimidazoles; Fluorinated hydrocarbons; Piperazines; Pyrimidines; Small molecules
Mechanism of Action Cyclin-dependent kinase 4 inhibitors; Cyclin-dependent kinase 6 inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Marketed Breast cancer
Phase III HER2 negative breast cancer; Liposarcoma; Prostate cancer
Phase II Adenocarcinoma; Brain cancer; Cholangiocarcinoma; Endometrial cancer; Ewing's sarcoma; Fallopian tube cancer; Glioblastoma; Mantle-cell lymphoma; Non-small cell lung cancer; Oesophageal cancer; Ovarian cancer; Pancreatic cancer; Peritoneal cancer; Solid tumours; Urogenital cancer
Phase I/II Head and neck cancer; Kaposi's sarcoma
Phase I Myelofibrosis
No development reported Cancer; Renal cell carcinoma

17 Oct 2025 Updated efficacy and adverse event data from the III monarchE trial for Breast cancer released by Eli Lilly and Company
19 Sep 2025 Eli Lilly and Company completes a phase-I/II trial in Solid tumours (Combination therapy, In adolescents, In children, In infants, Second-line therapy or greater, In adults) in Australia, Belgium, France, Germany, Italy, Japan, Spain, the US (PO, Tablet) (NCT04238819) (EudraCT2019-002931-27)
27 Aug 2025 Updated efficacy data from the phase III monarchE trial in Breast cancer released by Eli Lilly and Company

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