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Abemaciclib - Eli Lilly and Company

Drug Profile

Abemaciclib - Eli Lilly and Company

Alternative Names: Abemaciclib mesylate; Bemaciclib; Bemaciclib mesylate; LY-2835219; Verzenio; Verzenios

Latest Information Update: 16 Jan 2020

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At a glance

  • Originator Eli Lilly and Company
  • Developer Dana-Farber Cancer Institute; Eli Lilly; Eli Lilly and Company; Jules Bordet Institute; M. D. Anderson Cancer Center; Memorial Sloan-Kettering Cancer Center; Merck Sharp & Dohme; Washington University School of Medicine
  • Class Aminopyridines; Antineoplastics; Benzimidazoles; Piperazines; Pyrimidines; Small molecules
  • Mechanism of Action Cyclin-dependent kinase 4 inhibitors; Cyclin-dependent kinase 6 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Breast cancer
  • Phase II Brain cancer; Cholangiocarcinoma; Endometrial cancer; Fallopian tube cancer; Gastric cancer; Glioblastoma; Liposarcoma; Mantle-cell lymphoma; Oesophageal cancer; Ovarian cancer; Pancreatic cancer; Peritoneal cancer; Prostate cancer; Solid tumours; Urogenital cancer
  • Phase I/II Head and neck cancer
  • Phase I Cancer; Non-small cell lung cancer; Renal cell carcinoma

Most Recent Events

  • 20 Dec 2019 Phase-I clinical trials in Prostate cancer (Combination therapy, Late-stage disease, Metastatic disease) in Japan (PO) (NCT04071262)
  • 02 Dec 2019 Phase-I/II clinical trials in Solid tumours (Combination therapy, Late-stage disease, Second-line therapy or greater) in Australia, USA (PO) (NCT04165031)
  • 21 Nov 2019 Eli Lilly and Company plans a phase I/II trial for Solid tumours (Combination therapy, Late-stage disease, Second-line therapy or greater) in USA, Australia, Canada, Spain (PO) (NCT04165031)
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