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Atezolizumab - Genentech

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Drug Profile

Atezolizumab - Genentech

Alternative Names: Anti-PDL-1-Genentech/Roche; MPDL-3280A; RG-7446; RG7446-42; RO-5541267; TECENTRIQ; Tecentriq SC

Latest Information Update: 28 Mar 2024

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At a glance

  • Originator Genentech; University Medical Center Groningen
  • Developer Amgen; ARCAGY/GINECO Group; Austrian Breast & Colorectal Cancer Study Group; AVEO Oncology; Basilea Pharmaceutica; BioLineRx; Chugai Pharmaceutical; Clovis Oncology; Dana-Farber Cancer Institute; Duke University; European Organisation for Research and Treatment of Cancer; European Thoracic Oncology Platform; Exelixis; Fondazione Michelangelo; Galecto Inc; Genentech; GERCOR; German Breast Group; Gradalis; H. Lee Moffitt Cancer Center and Research Institute; Immune Design; Incyte Corporation; Johns Hopkins University; Kaiser Permanente; M. D. Anderson Cancer Center; Memorial Sloan-Kettering Cancer Center; National Cancer Center (Korea); National Cancer Institute (USA); Netherlands Cancer Institute; NSABP Foundation; Nykode Therapeutics; Oncolytics Biotech; Roche; Roche Pharma AG; Sanofi; University Hospital Southampton NHS Foundation Trust; University Medical Center Groningen; University of California; University of California at San Francisco; University of Florida; University of Oklahoma; Yale University
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Cytotoxic T lymphocyte stimulants; Programmed cell death-1 ligand-1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Oesophageal cancer; Malignant melanoma; Soft tissue sarcoma; Small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Breast cancer; Liver cancer; Malignant melanoma; Non-small cell lung cancer; Small cell lung cancer; Urogenital cancer
  • Preregistration Solid tumours
  • Phase III Bladder cancer; Cervical cancer; Colorectal cancer; Fallopian tube cancer; Gastrointestinal cancer; Malignant-mesothelioma; Oesophageal cancer; Ovarian cancer; Peritoneal cancer; Prostate cancer; Renal cell carcinoma
  • Phase II Adrenocortical carcinoma; Anal cancer; Biliary cancer; Brain metastases; Chronic lymphocytic leukaemia; Cutaneous T-cell lymphoma; Diffuse large B cell lymphoma; Endometrial cancer; Gastric cancer; Gynaecological cancer; Head and neck cancer; HER2 positive breast cancer; Malignant thymoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Penile cancer; Phaeochromocytoma; Rectal cancer; Soft tissue sarcoma; Squamous cell cancer; Thyroid cancer; Waldenstrom's macroglobulinaemia
  • Phase I/II Acute myeloid leukaemia; Cholangiocarcinoma; Follicular lymphoma; Gallbladder cancer; Glioblastoma; Hodgkin's disease; Neuroendocrine tumours; Non-Hodgkin's lymphoma; Pancreatic cancer
  • Phase I Haematological malignancies; Multiple myeloma
  • Discontinued Myelodysplastic syndromes

Most Recent Events

  • 13 Mar 2024 Roche completes a phase I trial in Colorectal cancer (Combination therapy, Late-stage disease, Second-line therapy or greater, Metastatic disease) in USA, Denmark, France, and Spain (IV) (NCT03866239)
  • 27 Feb 2024 Genentech completes a phase II trial in Solid tumours (Inoperable/Unresectable, Late-stage disease, Metastatic disease) in USA (PO) (NCT04632992)
  • 21 Feb 2024 Discontinued - Phase-III for Head and neck cancer (Late-stage disease, Adjuvant therapy) in Japan (IV) (Chugai pharmaceutical pipeline, February 2024 )
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