Atezolizumab - Genentech

Drug Profile

Atezolizumab - Genentech

Alternative Names: Anti-PDL-1-Genentech/Roche; MPDL-3280A; RG-7446; RO-5541267; TECENTRIQ

Latest Information Update: 08 Aug 2018

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At a glance

  • Originator Genentech; University Medical Center Groningen
  • Developer Amgen; ARCAGY/GINECO Group; BioLineRx; Chugai Pharmaceutical; Clovis Oncology; Dana-Farber Cancer Institute; European Organisation for Research and Treatment of Cancer; Exelixis; Fondazione Michelangelo; Genentech; GERCOR; Gradalis; Immune Design; Incyte Corporation; M. D. Anderson Cancer Center; National Cancer Center (Korea); National Cancer Institute (USA); Netherlands Cancer Institute; Roche; Sanofi; University Hospital Southampton NHS Foundation Trust; University Medical Center Groningen; University of California at San Francisco; University of California System; Yale University
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Programmed cell death-1 ligand-1inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer; Urogenital cancer
  • Phase III Bladder cancer; Breast cancer; Fallopian tube cancer; Head and neck cancer; Hepatocellular carcinoma; Malignant melanoma; Ovarian cancer; Peritoneal cancer; Prostate cancer; Renal cell carcinoma; Small cell lung cancer
  • Phase II Anal cancer; Brain metastases; Chronic lymphocytic leukaemia; Colorectal cancer; Diffuse large B cell lymphoma; Gastric cancer; Gynaecological cancer; Mantle-cell lymphoma; Marginal-zone-B-cell-lymphoma; Oesophageal cancer; Soft tissue sarcoma; Solid tumours; Thyroid cancer; Waldenstrom's macroglobulinaemia
  • Phase I/II Acute myeloid leukaemia; Follicular lymphoma; Glioblastoma; Pancreatic cancer
  • Phase I Multiple myeloma; Non-Hodgkin's lymphoma
  • No development reported Haematological malignancies
  • Discontinued Myelodysplastic syndromes

Most Recent Events

  • 31 Jul 2018 Roche initiates a phase II trial for Melanoma (Combination therapy, Metastatic disease, Second-line therapy or greater) in Spain (EudraCT2018-000759-41)
  • 26 Jul 2018 Discontinued - Phase-I for Solid tumours (Combination therapy with cobimetinib, Late-stage disease, Metastatic disease) in USA, Germany, Australia, Singapore, South Korea, Canada (IV) (NCT01988896) (Roche pipeline, July 2018)
  • 26 Jul 2018 Discontinued - Phase-III for Colorectal cancer (Combination therapy with cobimetinib, Inoperable/Unresectable, Late-stage disease, Second-line therapy or greater) in USA, United Kingdom, Spain, Russia, Poland, South Korea, Italy, Hong Kong, Canada, Belgium, Australia (IV) (NCT02788279) (Roche pipeline, July 2018)
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