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At a glance
Originator
Abbott Laboratories; Genentech; Walter and Eliza Hall Institute of Medical Research
Developer
AbbVie; Celgene Corporation; Dana-Farber Cancer Institute; Emory University; Fondazione Italiana Linfomi; Genentech; Janssen Research & Development; M. D. Anderson Cancer Center; Merck & Co; Nantes University Hospital; National Cancer Institute (USA); Nordic Lymphoma Group; Pharmacyclics; Roche; Syros Pharmaceuticals; University Health Network
Class
Antineoplastics; Benzamides; Heterocyclic bicyclo compounds; Piperazines; Pyrans; Pyridines; Pyrroles; Small molecules; Sulfonamides
Mechanism of Action
Apoptosis stimulants; Proto-oncogene protein c-bcl-2 inhibitors
Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
Yes
-
Diffuse large B cell lymphoma; Acute myeloid leukaemia; Chronic lymphocytic leukaemia; Multiple myeloma
New Molecular Entity
Yes
Highest Development Phases
Marketed
Chronic lymphocytic leukaemia
Registered
Acute myeloid leukaemia
Phase III
Mantle-cell lymphoma; Multiple myeloma; Myelodysplastic syndromes
Phase II
Breast cancer; Diffuse large B cell lymphoma; Follicular lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma; T-cell prolymphocytic leukaemia; Waldenstrom's macroglobulinaemia
Phase I
B-cell lymphoma; Blastic plasmacytoid dendritic cell neoplasm; Cancer; Haematological malignancies; Non-small cell lung cancer; Small cell lung cancer
No development reported
Systemic lupus erythematosus
Most Recent Events
06 Mar 2023
AbbVie re-initiates a phase III trial for Acute myeloid leukaemia (Combination therapy, First-line therapy) in USA (PO) (NCT03709758) (700300873
25 Jan 2023
Loxo Oncology initiates a phase II trial for in Mantle-cell lymphoma (Combination therapy, Second-line therapy or greater) in Finland (PO) (NCT05529069)
16 Jan 2023
3748386- NIO sponsored abstract of a well launched drug, hence not captured
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