Venetoclax - AbbVie/Genentech
Alternative Names: A-1195425.0; ABT 0199; ABT 199; GDC-0199; RG-7601; RO-5537382; Venclexta; VENCLYXTO; VenclyxtoLatest Information Update: 26 Jul 2024
At a glance
- Originator Abbott Laboratories; Genentech; Walter and Eliza Hall Institute of Medical Research
- Developer AbbVie; Celgene Corporation; Dana-Farber Cancer Institute; Eli Lilly and Company; Emory University; Genentech; Janssen Research & Development; M. D. Anderson Cancer Center; Merck & Co; Nantes University Hospital; National Cancer Institute (USA); Nordic Lymphoma Group; Pharmacyclics; Roche; Syros Pharmaceuticals; University Health Network
- Class Antineoplastics; Benzamides; Heterocyclic bicyclo compounds; Piperazines; Pyrans; Pyridines; Pyrroles; Small molecules; Sulfonamides
- Mechanism of Action Apoptosis stimulants; Proto-oncogene protein c-bcl-2 inhibitors
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Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Marketed Chronic lymphocytic leukaemia
- Registered Acute myeloid leukaemia
- Phase III Mantle-cell lymphoma; Myelodysplastic syndromes
- Phase II Breast cancer; Diffuse large B cell lymphoma; Follicular lymphoma; Marginal zone B-cell lymphoma; Multiple myeloma; Non-Hodgkin's lymphoma; T-cell prolymphocytic leukaemia; Waldenstrom's macroglobulinaemia
- Phase I/II Chronic myelomonocytic leukaemia; Precursor cell lymphoblastic leukaemia-lymphoma; Prostate cancer
- Phase I B-cell lymphoma; Blastic plasmacytoid dendritic cell neoplasm; Cancer; Haematological malignancies; Non-small cell lung cancer; Small cell lung cancer
- No development reported Systemic lupus erythematosus
Most Recent Events
- 09 Jul 2024 Hoffmann-La Roche terminates a phase I trial in Diffuse large B cell lymphoma (Combination therapy, First-line therapy) in USA, Italy, France, Spain (IV) due to strategic prioritization (NCT04790903)
- 26 Jun 2024 Pharmacyclics completes a phase-III clinical trials in Mantle-cell lymphoma (Combination therapy, First-line therapy, Second-line therapy or greater) in USA, Australia, Ukraine, Turkey, South Korea, Spain, Poland, Netherlands, Italy, Hungary, Greece, Germany, France, Czech Republic, Canada, Belgium (PO) (NCT03112174)
- 21 Jun 2024 AbbVie terminated a phase I trial for a new high drug load tablet formulation in healthy female volunteers in fed and fasting conditions in the US due to strategic considerations (NCT06070948)