Venetoclax - AbbVie/Genentech

Drug Profile

Venetoclax - AbbVie/Genentech

Alternative Names: A-1195425.0; ABT 199; GDC-0199; RG-7601; RO-5537382; Venclexta; VENCLYXTO

Latest Information Update: 13 Aug 2018

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At a glance

  • Originator Abbott Laboratories; Genentech; Walter and Eliza Hall Institute of Medical Research
  • Developer AbbVie; Dana-Farber Cancer Institute; Genentech; Janssen Research & Development; Merck & Co; Nantes University Hospital; Pharmacyclics; Roche
  • Class Antineoplastics; Benzamides; Heterocyclic bicyclo compounds; Piperazines; Pyrans; Pyridines; Pyrroles; Small molecules; Sulfonamides
  • Mechanism of Action Apoptosis stimulants; Proto-oncogene protein c-bcl-2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Diffuse large B cell lymphoma; Acute myeloid leukaemia; Chronic lymphocytic leukaemia; Multiple myeloma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Chronic lymphocytic leukaemia
  • Preregistration Acute myeloid leukaemia
  • Phase III Mantle-cell lymphoma; Multiple myeloma
  • Phase II Breast cancer; Diffuse large B cell lymphoma; Follicular lymphoma; Myelodysplastic syndromes; Non-Hodgkin's lymphoma; Waldenstrom's macroglobulinaemia
  • Phase I Cancer; Precursor cell lymphoblastic leukaemia-lymphoma; Systemic lupus erythematosus

Most Recent Events

  • 23 Jul 2018 Phase-I clinical trials in Acute myeloid leukaemia (Combination therapy, Second-line therapy or greater) in Spain (PO) (NCT03484520)
  • 16 Jul 2018 Preliminary efficacy data from a phase I trial in Precursor cell lymphoblastic leukaemia-lymphoma presented at the 23rd Congress of the European Haematology Association (EHA-2018)
  • 12 Jul 2018 Phase-II clinical trials in Breast cancer (Late-stage disease, Second-line therapy or greater, Recurrent) in USA (PO) (NCT03584009)
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