Arfolitixorin - Isofol

Drug Profile

Arfolitixorin - Isofol

Alternative Names: 5-10-Methylenetetrahydrofolate; 6R-MTHF; [6R] 5,10-methylenetetrahydrofolate; Arfolitixorin; Arfolitixorin hemisulfate; ISO-901; Modufolin; Modulfolin

Latest Information Update: 06 Sep 2018

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At a glance

  • Originator Merck Eprova
  • Developer Isofol Medical
  • Class 3-ring heterocyclic compounds; Antineoplastics; Chemoprotectants; Chemosensitisers; Folic-acids; Imidazolidines; Pyrimidinones; Small molecules; Tetrahydrofolates
  • Mechanism of Action Antimetabolites; Thymidylate synthase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Colorectal cancer; Osteosarcoma
  • Phase I/II Rectal cancer

Most Recent Events

  • 31 Aug 2018 Isofol Medical has patent protection for arfolitixorin in USA
  • 16 May 2018 Isofol Medical plans the pivotal phase III ISO-CC-007 trial for Colorectal cancer (Late-stage disease, Metastatic disease, First-line therapy) in USA and Europe
  • 15 Jan 2018 Updated efficacy data from a phase I/II dose cohort trial in metastatic Colorectal cancer released by Isofol Medical
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