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Monalizumab - Innate Pharma

Drug Profile

Monalizumab - Innate Pharma

Alternative Names: Anti-NKG2A; IPH-22; IPH-2201; IPH-22XX; NN-8765; NNC 0141-0000-0100

Latest Information Update: 05 Dec 2023

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At a glance

  • Originator Novo Nordisk
  • Developer AstraZeneca; Innate Pharma; Istituto Clinico Humanitas; NCIC Clinical Trials Group; Netherlands Cancer Institute; Novo Nordisk
  • Class Anti-inflammatories; Antineoplastics; Antirheumatics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; NK cell lectin-like receptor subfamily C antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Non-small cell lung cancer
  • Phase II Acute myeloid leukaemia; HER2 positive breast cancer; Myelodysplastic syndromes; Small cell lung cancer; Squamous cell cancer
  • Phase I/II Cervical cancer; Chronic lymphocytic leukaemia; Endometrial cancer; Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Solid tumours
  • No development reported Haematological malignancies
  • Discontinued Inflammation; Rheumatoid arthritis

Most Recent Events

  • 30 Nov 2023 Assistance Publique plans a phase II trial for Cancer (Combination therapy, Metastatic disease, Late-stage disease,Second-line therapy or greater) in France (NCT06152523)
  • 20 Oct 2023 Efficacy and adverse events data from the phase II UPSTREAM trial in squamous cell cancer presented at the 48th European Society for Medical Oncology Congress (ESMO-2023)
  • 20 Oct 2023 - Safety and efficacy data from the phase III INTERLINK-1 trial in Squamous cell carcinoma (Combination therapy, Metastatic disease, Recurrent, Second-line therapy or greater) presented at the 48th European Society for Medical Oncology Congress (ESMO-2023)
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