Drug Profile

Monalizumab - Innate Pharma

Alternative Names: Anti-NKG2A; IPH-22; IPH-2201; IPH-22XX; NN-8765; NNC 0141-0000-0100

Latest Information Update: 29 Dec 2024

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At a glance

Originator Novo Nordisk
Developer AstraZeneca; Innate Pharma; Istituto Clinico Humanitas; NCIC Clinical Trials Group; Netherlands Cancer Institute; Novo Nordisk
Class Anti-inflammatories; Antineoplastics; Antirheumatics; Immunotherapies; Monoclonal antibodies
Mechanism of Action Antibody-dependent cell cytotoxicity; NK cell lectin-like receptor subfamily C antagonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Phase III Non-small cell lung cancer
Phase II Acute myeloid leukaemia; Bladder cancer; HER2 positive breast cancer; Myelodysplastic syndromes; Small cell lung cancer; Squamous cell cancer
Phase I/II Cervical cancer; Chronic lymphocytic leukaemia; Endometrial cancer; Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Solid tumours
No development reported Haematological malignancies
Discontinued Inflammation; Rheumatoid arthritis

12 Dec 2024 Phase-II clinical trials in Bladder cancer (Combination therapy) in USA (IV) (NCT06503614)
09 Sep 2024 Efficacy and adverse event data from the phase II NeoCOAST 2 trial released by Innate Pharma
31 May 2024 Adverse events and efficacy data from a phase II COAST trial in Non-small cell lung cancer presented at the 60th Annual Meeting of the American Society of Clinical Oncology (ASCO-2024)

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