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Monalizumab - Innate Pharma/MedImmune

Drug Profile

Monalizumab - Innate Pharma/MedImmune

Alternative Names: Anti-NKG2A; IPH-22; IPH-2201; IPH-22XX; NN-8765; NNC 0141-0000-0100

Latest Information Update: 01 Oct 2020

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At a glance

  • Originator Novo Nordisk
  • Developer AstraZeneca; Innate Pharma; MedImmune; NCIC Clinical Trials Group; Netherlands Cancer Institute; Novo Nordisk
  • Class Antineoplastics; Antirheumatics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; NK cell lectin-like receptor subfamily C antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Breast cancer; Head and neck cancer; Non-small cell lung cancer
  • Phase I/II Cervical cancer; Chronic lymphocytic leukaemia; Endometrial cancer; Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Solid tumours
  • Phase I Haematological malignancies
  • Discontinued Inflammation; Rheumatoid arthritis

Most Recent Events

  • 21 Sep 2020 Medimmune withdraws a planned phase II COLUMBIA-2 trial for microsatellite-stable Colorectal cancer (Combination therapy, adjuvant therapy, First-line therapy) in Australia, Canada, France, South Korea, Spain, Taiwan and in the US (IV), due to change in standard of care landscape (NCT04145193)
  • 22 Jun 2020 Pooled pharmacokinetics data from a phase Ib/II in Solid tumours and phase I/II trial in Head and neck cancer presented at the 111th Annual Meeting of the American Association for Cancer Research (AACR-2020)
  • 04 Jun 2020 Phase-II clinical trials in Breast cancer (Combination therapy, Metastatic disease, Second-line therapy or greater, In adults, In the elderly) in Netherlands (IV) (EudraCT2020-000849-14)
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