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Avadomide - Celgene Corporation

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Drug Profile

Avadomide - Celgene Corporation

Alternative Names: CC 122

Latest Information Update: 08 Oct 2024

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At a glance

  • Originator Celgene Corporation
  • Developer Bristol-Myers Squibb; Celgene Corporation; H. Lee Moffitt Cancer Center and Research Institute; Juno Therapeutics
  • Class Antineoplastics; Piperidones; Quinazolines
  • Mechanism of Action CRBN protein modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Malignant melanoma
  • Phase I/II Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Follicular lymphoma; Liver cancer; Non-Hodgkin's lymphoma
  • Phase I Solid tumours
  • No development reported Glioblastoma; Multiple myeloma

Most Recent Events

  • 08 Oct 2024 Celgene terminates a phase I trial in Solid tumours (Late-stage disease) in Japan das it is replaced with another clinical trial (NCT02509039)
  • 06 May 2024 Celgene terminates a phase I trial in Non-Hodgkin lymphoma (Late-stage disease) in Japan das it is replaced with another clinical trial (NCT02509039)
  • 12 Dec 2023 Celgene terminates a phase I trial in Diffuse large B-cell lymphoma (Combination therapy, Second-line therapy or greater) in Canada, Italy, USA and France (PO) as the trial was replaced with another clinical trial (NCT02031419)

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