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Ciforadenant - Corvus Pharmaceuticals

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Drug Profile

Ciforadenant - Corvus Pharmaceuticals

Alternative Names: CPI-444; V 81444

Latest Information Update: 08 Apr 2025

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At a glance

  • Originator Vernalis
  • Developer Corvus Pharmaceuticals; Genentech; M. D. Anderson Cancer Center; Vernalis
  • Class Amines; Antineoplastics; Antiparkinsonians; Behavioural disorder therapies; Furans; Pyridines; Pyrimidines; Small molecules; Triazoles
  • Mechanism of Action Adenosine A2A receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Renal cell carcinoma
  • Phase I/II Non-small cell lung cancer
  • Phase I Multiple myeloma; Solid tumours
  • No development reported Attention-deficit hyperactivity disorder; Cancer; Parkinson's disease

Most Recent Events

  • 25 Mar 2025 M.D. Anderson Cancer Center and Kidney Cancer Research Consortium complete enrolment in a phase Ib/II trial for Renal cell carcinoma (Combination therapy, Late-stage disease, metastatic disease, First-line therapy) in the US (PO), prior to March 2025
  • 09 Nov 2024 Pharmacodynamics data from preclinical studies in Solid tumours released by Corvus Pharmaceuticals
  • 05 Jan 2024 Ciforadenant is still in phase I trials for Solid tumours in Australia and the USA (NCT03454451)

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