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Linerixibat - GSK

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Drug Profile

Linerixibat - GSK

Alternative Names: GSK 2330672; GSK 672; Lynavoy

Latest Information Update: 24 Mar 2026

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At a glance

  • Originator GlaxoSmithKline
  • Developer GSK
  • Class Antihyperglycaemics; Antipruritics; Benzene derivatives; Carboxylic acids; Ethers; Small molecules; Thiazepines
  • Mechanism of Action Sodium-bile acid cotransporter inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pruritus
  • New Molecular Entity Yes

Highest Development Phases

  • Registered Pruritus
  • Discontinued Cholestasis; Type 2 diabetes mellitus

Most Recent Events

  • 24 Mar 2026 Discontinued - Phase-I for Cholestasis (In volunteers) in Japan (PO), before March 2026 (GSK pipeline, March 2026)
  • 24 Mar 2026 Discontinued - Phase-I for Cholestasis (In volunteers) in United Kingdom (IV), before March 2026 (GSK pipeline, March 2026)
  • 24 Mar 2026 Discontinued - Phase-I for Cholestasis (In volunteers) in United Kingdom (PO), before March 2026 (GSK pipeline, March 2026)

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