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Tovorafenib - Day One Biopharmaceuticals

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Drug Profile

Tovorafenib - Day One Biopharmaceuticals

Alternative Names: AMG-2112819; BIIB 024 - Day One Biopharmaceuticals; BIIB-024; BSK 1369; DAY-101; MLN 2480; OJEMDA; Ojemda; TAK 580

Latest Information Update: 04 May 2026

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At a glance

  • Originator Biogen Idec; Sunesis Pharmaceuticals
  • Developer Day One Biopharmaceuticals; National Cancer Institute (USA); Takeda Oncology
  • Class Amides; Antineoplastics; Pyridines; Pyrimidines; Small molecules; Thiazoles
  • Mechanism of Action Raf kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioma; Malignant melanoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Glioma
  • Phase II Craniopharyngioma; Langerhans cell histiocytosis; Solid tumours
  • Discontinued Malignant melanoma

Most Recent Events

  • 23 Apr 2026 Day One Biopharmaceuticals has been acquired by Servier
  • 22 Apr 2026 Registered for Glioma (In children, In infants, In adolescents, In adults, Second-line therapy or greater) in European Union, Norway, Iceland, Liechtenstein (PO)
  • 22 Apr 2026 Tovorafenib receives Orphan Drug status for Glioma in Russia

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