Anetumab ravtansine

Drug Profile

Anetumab ravtansine

Alternative Names: Anti-mesothelin antibody-drug conjugate BAY 94-9343; Anti-mesothelin-ADC-BAY-94-9343; BAY-94-9343; BAY-94-9343-SPDB-DM4

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Bayer HealthCare
  • Developer Bayer HealthCare; ImmunoGen; MorphoSys; National Cancer Institute (USA)
  • Class Antineoplastics; Immunoconjugates; Immunotoxins; Maytansinoids; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; Mitosis inhibitors; Tubulin inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mesothelioma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Lung cancer; Mesothelioma; Pancreatic cancer; Solid tumours
  • Phase I Non-small cell lung cancer; Ovarian cancer

Most Recent Events

  • 06 Mar 2018 Mayo Clinic in collaboration with National Cancer Institute, plans a phase I/II trial for Non-small cell lung cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (NCT03455556)
  • 26 Oct 2017 Interim efficacy and adverse events data from phase Ib trial in Mesothelioma and Non-small cell lung cancer was presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics 2017 (AACR-NCI-EORTC - 2017)
  • 04 Jul 2017 Bayer completes a phase I trial in Solid tumours (Late-stage disease, Second-line therapy or greater) in Japan (IV) (NCT02485119)
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