MK 8457

Drug Profile

MK 8457

Alternative Names: MK-8457

Latest Information Update: 03 Jun 2014

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At a glance

  • Originator Merck & Co
  • Class Antihypertensives
  • Mechanism of Action Undefined mechanism
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Hypertension; Rheumatoid arthritis

Most Recent Events

  • 30 Apr 2014 Discontinued - Phase-I for Hypertension in USA (PO)
  • 30 Apr 2014 Discontinued - Phase-II for Rheumatoid arthritis (combination therapy) in USA, Australia, Canada, Chile, Colombia, Denmark, France, Germany, Hungary, Japan, Latvia, Lithuania, Moldova, New Zealand, Peru, Poland, South Africa, South Korea, Spain, Taiwan and United Kingdom (PO)
  • 01 Oct 2013 Merck & Co. terminates a phase II trial in Rheumatoid arthritis (combination therapy) in USA, Australia, Colombia, Denmark, France, Greece, Hungary, Italy, New Zealand, Poland, South Africa, South Korea, Spain and United Kingdom (NCT01651936; EudraCT2012-002181-12)
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