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Nibrozetone - EpicentRx

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Drug Profile

Nibrozetone - EpicentRx

Alternative Names: RRx-001

Latest Information Update: 12 Aug 2024

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At a glance

  • Originator RadioRx
  • Developer EpicentRx; SciClone Pharmaceuticals; The University of Queensland
  • Class Anti-inflammatories; Antianaemics; Antidementias; Antifibrotics; Antineoplastics; Antiparkinsonians; Azetidines; Cytoprotectives; Nitro compounds; Radiosensitisers; Small molecules
  • Mechanism of Action CD47 antigen inhibitors; Free radical stimulants; Inflammasome inhibitors; Macrophage stimulants; NLRP3 protein inhibitors; Proto-oncogene protein c-myc inhibitors; SIRPA protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Small cell lung cancer; Neuroendocrine tumours; Glioblastoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Small cell lung cancer
  • Phase II Cholangiocarcinoma; Colorectal cancer; Mucositis; Neuroendocrine tumours; Non-small cell lung cancer; Ovarian cancer
  • Phase I CNS cancer; Solid tumours
  • Preclinical Alzheimer's disease; Amyotrophic lateral sclerosis; Endometriosis; Myocardial infarction; Parkinson's disease; Pulmonary fibrosis
  • No development reported Brain metastases; Glioblastoma; Glioma; Lymphoma; Multiple myeloma; Sickle cell anaemia

Most Recent Events

  • 29 Jul 2024 EpicentRx terminates the phase I trial in Solid tumours (Combination therapy, In adolescents, In children, In infants, Second-line therapy or greater, In adults) in USA due to low enrollment (IV) (NCT04525014)
  • 02 Apr 2024 EpicentRx initiates a phase II KEVLARx trial in Mucositis in USA (IV,Injection) (NCT05966194)
  • 28 Dec 2023 No recent reports of development identified for phase-I development in Brain metastases(Combination therapy) in USA (IV)

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