GKT 831

Drug Profile

GKT 831

Alternative Names: GKT-137831; GKT-831; UNII-45II35329V

Latest Information Update: 08 Jun 2018

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At a glance

  • Originator GenKyoTex
  • Developer GenKyoTex; University of California, Davis; University of California, San Diego
  • Class Pyrazoles; Pyridines; Small molecules
  • Mechanism of Action NOX1 protein inhibitors; NOX4 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Idiopathic pulmonary fibrosis; Systemic scleroderma
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Diabetic nephropathies; Primary biliary cirrhosis
  • No development reported Hepatic fibrosis; Idiopathic pulmonary fibrosis; Non-alcoholic steatohepatitis; Systemic scleroderma
  • Discontinued Atherosclerosis; Bone disorders; Eye-Disorders

Most Recent Events

  • 07 May 2018 An independent Safety Monitoring Board (SMB) recommends continuation of a phase II trial in Primary biliary cirrhosis
  • 28 Jun 2017 Genkyotex plans a phase II trial for Type 1 diabetes mellitus (associated with diabetic kidney disease) in Australia
  • 27 Jun 2017 Phase-II clinical trials in Primary biliary cirrhosis in USA (PO)
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