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PIM 447

Drug Profile

PIM 447

Alternative Names: LGH-447; PIM447

Latest Information Update: 23 Jul 2019

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At a glance

  • Originator Novartis
  • Developer Novartis; Novartis Oncology
  • Class Antineoplastics
  • Mechanism of Action Proto oncogene proteins c pim 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Multiple myeloma
  • Phase I Acute myeloid leukaemia; Myelodysplastic syndromes
  • No development reported Myelofibrosis

Most Recent Events

  • 17 Jul 2019 Phase-I development is still ongoing in Spain (NCT01456689)
  • 05 Jun 2019 Novartis completes a phase I trial in Multiple myeloma (Second-line therapy or greater) in USA, Germany, Singapore and Spain (NCT01456689)
  • 18 Apr 2019 Novartis completes a phase I trial in Myelodysplastic syndromes and Acute myeloid leukaemia (Monotherapy, Combination therapy, Second-line therapy or greater) in USA, Italy, Australia, France, Germany, Japan and Netherlands (PO) (NCT02078609)
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