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Miransertib - Merck & Co

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Drug Profile

Miransertib - Merck & Co

Alternative Names: ARQ 092; MK 7075

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator ArQule; Daiichi Sankyo Company
  • Developer ArQule; Merck & Co; Merck Sharp & Dohme Corp.; National Human Genome Research Institute
  • Class Antineoplastics; Cardiovascular therapies; Cyclobutanes; Imidazoles; Pyridines; Small molecules
  • Mechanism of Action Proto-oncogene protein c-akt inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Proteus syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Growth disorders; Proteus syndrome
  • Discontinued Congenital heart defects; Endometrial cancer; Lymphoma; Ovarian cancer; Solid tumours; Vaso-occlusive crisis

Most Recent Events

  • 08 Mar 2023 Discontinued - Phase-I for Endometrial cancer (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO)
  • 08 Mar 2023 Discontinued - Phase-I for Lymphoma (Monotherapy, Second-line therapy or greater) in USA (PO)
  • 08 Mar 2023 Discontinued - Phase-I for Ovarian cancer (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO)

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