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Varoglutamstat - Vivoryon Therapeutics

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Drug Profile

Varoglutamstat - Vivoryon Therapeutics

Alternative Names: PQ-912; SIM 0408; SIM-0801

Latest Information Update: 10 Dec 2025

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At a glance

  • Originator Probiodrug
  • Developer University of California, San Diego; Vivoryon Therapeutics
  • Class Anti-inflammatories; Antidementias; Benzimidazoles; Imidazolidines; Neuroprotectants; Small molecules
  • Mechanism of Action Glutaminyl-peptide cyclotransferase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Diabetic nephropathies
  • Preclinical Inflammation
  • Phase Unknown Renal failure
  • Discontinued Alzheimer's disease; Huntington's disease

Most Recent Events

  • 27 Jul 2025 Efficacy data from the phase-II VIVIAD trial in Alzheimer's disease presented at Alzheimer's Association International Conference 2025 (AAIC-2025)
  • 27 Jul 2025 Updated efficacy and adverse events data from a phase IIa VIVA-MIND trial in Alzheimer's disease presented at the Alzheimer's Association International Conference 2025 (AAIC-2025)
  • 27 May 2025 The United States Patent and Trademark Office (USPTO) has granted an additional patent for varoglutamstat

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