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Stenoparib - Allarity Therapeutics

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Drug Profile

Stenoparib - Allarity Therapeutics

Alternative Names: 2X-121; 2X-121/PARPi; E-7449; MGI 25036

Latest Information Update: 06 Feb 2026

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At a glance

  • Originator Eisai Co Ltd
  • Developer Allarity Therapeutics
  • Class Antineoplastics; Antivirals; Isoindoles; Pyridazines; Quinazolines; Small molecules
  • Mechanism of Action Poly(ADP-ribose) polymerase 2 inhibitors; Poly(ADP-ribose) polymerase-1 inhibitors; Tankyrase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Breast cancer; Ovarian cancer
  • Phase I/II Small cell lung cancer; Solid tumours
  • No development reported B-cell lymphoma; COVID 2019 infections; Neuroblastoma; Renal cancer; Sarcoma

Most Recent Events

  • 03 Feb 2026 Phase-I/II clinical trials in Small cell lung cancer (Late-stage disease, Second-line therapy or greater, Combination therapy) in USA (PO) (NCT06681220)
  • 28 Jan 2026 No recent reports of development identified for phase-I development in Ovarian-cancer(Combination therapy, Second-line therapy or greater) in Unknown (PO, Capsule)
  • 31 Dec 2025 Allarity Therapeutics announces intention to submit NDA application for approval in Ovarian cancer

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