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Stenoparib - Allarity Therapeutics

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Drug Profile

Stenoparib - Allarity Therapeutics

Alternative Names: 2X-121; 2X-121/PARPi; E-7449; MGI 25036

Latest Information Update: 12 Jun 2025

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At a glance

  • Originator Eisai Co Ltd
  • Developer Allarity Therapeutics
  • Class Antineoplastics; Antivirals; Isoindoles; Pyridazines; Quinazolines; Small molecules
  • Mechanism of Action Poly(ADP-ribose) polymerase 2 inhibitors; Poly(ADP-ribose) polymerase-1 inhibitors; Tankyrase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Breast cancer; Ovarian cancer
  • Phase I/II Solid tumours
  • No development reported B-cell lymphoma; COVID 2019 infections; Neuroblastoma; Renal cancer; Sarcoma

Most Recent Events

  • 04 Jun 2025 Allarity Therapeutics enters into a research agreement with Indiana Biosciences Research Institute for understanding of the dual mechanism of action of Stenoparib
  • 02 Jun 2025 Phase-II clinical trials in Ovarian cancer (Recurrent, Second-line therapy or greater, Monotherapy, Late-stage disease) (PO)
  • 09 May 2025 Allarity Therapeutics plans a phase II trial for Small-cell lung cancer (Combination therapy) by the third quarter of 2025

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