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Sirexatamab - Leap Therapeutics

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Drug Profile

Sirexatamab - Leap Therapeutics

Alternative Names: DKN-01; LY-2812176

Latest Information Update: 20 Aug 2024

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At a glance

  • Originator Eli Lilly and Company
  • Developer BeiGene; Leap Therapeutics
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action DKK1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gastric cancer; Oesophageal cancer
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Biliary cancer; Colorectal cancer; Endometrial cancer; Gastric cancer; Liver cancer; Oesophageal cancer; Ovarian cancer
  • Phase I/II Prostate cancer
  • No development reported Multiple myeloma; Non-small cell lung cancer; Sarcoma; Solid tumours; Squamous cell cancer; Uterine cancer

Most Recent Events

  • 12 Aug 2024 Efficacy data from the phase II DeFianCe trial in Colorectal cancer released by Leap Therapeutics
  • 27 Mar 2024 Leap Therapeutics and BeiGene has patent pending for Sirexatamab in combination with tislelizumab in the US
  • 27 Mar 2024 Leap Therapeutics has one international patents pending for Sirexatamab in the US

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