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GB 004

Drug Profile

GB 004

Alternative Names: AKB-4924; GB-004

Latest Information Update: 15 Oct 2020

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At a glance

  • Originator Procter & Gamble
  • Developer Aerpio Pharmaceuticals; Gossamer Bio
  • Class Anti-inflammatories; Antiulcers; Piperazines; Pyridones; Small molecules
  • Mechanism of Action Hypoxia inducible factor 1 modulators; Prolyl hydroxylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Ulcerative colitis
  • No development reported Inflammatory bowel diseases

Most Recent Events

  • 13 Oct 2020 Efficacy data from a phase Ib trial in Ulcerative colitis released by Gossamer
  • 30 Sep 2020 Phase-II clinical trials in Ulcerative colitis (In the elderly, In adults) in USA (PO) (NCT04556383)
  • 11 Aug 2020 Gossamer Bio plans a phase II SHIFT-UC trial for Ulcerative colitis in the second half of 2020 (NCT04556383) (EudraCT2020-002306-12)
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