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MK 8353

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Drug Profile

MK 8353

Alternative Names: MK-8353; SCH-900353

Latest Information Update: 05 Dec 2024

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At a glance

  • Originator Schering-Plough
  • Developer Merck Sharp & Dohme
  • Class Antineoplastics; Dihydropyridines; Indazoles; Pyrrolidines
  • Mechanism of Action Mitogen-activated protein kinase 1 inhibitors; Mitogen-activated protein kinase 3 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • No development reported Colorectal cancer; Solid tumours

Most Recent Events

  • 13 Nov 2024 Merck Sharp & Dohme terminates a phase Ib MK-8353-013 trial in Colorectal cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) and Solid tumours (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Canada, USA (PO) (NCT02972034)
  • 28 Mar 2023 No recent reports of development identified for phase-I development in Colorectal-cancer(Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Canada (PO, Capsule)
  • 28 Mar 2023 No recent reports of development identified for phase-I development in Colorectal-cancer(Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO, Capsule)

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