Idasanutlin - Roche

Drug Profile

Idasanutlin - Roche

Alternative Names: RG-7388; RO-5503781

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Roche
  • Developer Mayo Clinic; National Cancer Institute (USA); NHS Greater Glasgow and Clyde; Roche; University of Glasgow
  • Class Aminobenzoic acids; Antineoplastics; Pyrrolidines; Small molecules
  • Mechanism of Action Proto-oncogene protein c mdm2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia
  • Phase II Polycythaemia vera
  • Phase I/II Diffuse large B cell lymphoma; Follicular lymphoma; Multiple myeloma; Non-Hodgkin's lymphoma; Prostate cancer
  • Phase I Cancer; Essential thrombocythaemia; Solid tumours

Most Recent Events

  • 28 Feb 2018 Roche completes the phase I/II MAdCaP trial in Prostate cancer (Combination therapy, Metastatic disease, Hormone refractory) in United Kingdom (PO) (ISRCTN38949950)
  • 09 Dec 2017 Efficacy, adverse events and pharmacodynamic data from a phase I trial in Polycythaemia vera and Essential thrombocythaemia presented at the 59th Annual Meeting and Exposition of the American Society of Hematology (ASH-Hem-2017)
  • 27 Nov 2017 Phase-I clinical trials in Solid tumours (In adults, In the elderly, Late-stage disease) in USA (PO) (NCT03362723)
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