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Belumosudil - Kadmon Pharmaceuticals

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Drug Profile

Belumosudil - Kadmon Pharmaceuticals

Alternative Names: Belumosudil mesylate - Kadmon Pharmaceuticals; BN-101; KD-025; KD025 mesylate; ME-3208; REZUROCK; Rholistiq; SAR445761; SLX-2119

Latest Information Update: 02 Apr 2024

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At a glance

  • Originator Surface Logix
  • Developer BK Pharmaceuticals; Kadmon Pharmaceuticals; Meiji Seika Pharma; Sanofi
  • Class Acetamides; Amines; Anti-inflammatories; Antifibrotics; Antipsoriatics; Antirheumatics; Hepatoprotectants; Indazoles; Phenyl ethers; Quinazolines; Skin disorder therapies; Small molecules
  • Mechanism of Action Rho-associated kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Graft-versus-host disease; Systemic scleroderma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Graft-versus-host disease
  • Phase III Lung transplant rejection
  • Phase II Idiopathic pulmonary fibrosis; Systemic scleroderma
  • Phase I Autoimmune disorders
  • Preclinical Multiple myeloma
  • Discontinued Non-alcoholic steatohepatitis; Plaque psoriasis; Rheumatoid arthritis; Systemic lupus erythematosus

Most Recent Events

  • 26 Mar 2024 Registered for Graft-versus-host disease in Japan (PO)
  • 11 Dec 2023 Kadmon Corporation terminates the phase II The ROCKstar Study in Graft-versus-host disease (In adolescents, In adults, Treatment-experienced) in USA (PO) due to the sponsor decision to prematurely terminate the study due to the challenges encountered in recruiting adolescent participants (NCT03640481)
  • 09 Dec 2023 Preclinical trials in Multiple myeloma in France (unspecified route) prior to December 2023
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