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Cenegermin - Dompe Farmaceutici

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Drug Profile

Cenegermin - Dompe Farmaceutici

Alternative Names: Cenegermin-bkbj; Nerve growth factor - Anabasis/Dompe; Ophtha-NGF; Ophtha-NGF Intravitreal; Oxervate; rhNGF; Sentinel

Latest Information Update: 15 May 2026

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At a glance

  • Originator Anabasis Pharma
  • Developer Anabasis Pharma; Dompe Farmaceutici; Ospedale San Raffaele
  • Class Anti-inflammatories; Antiglaucomas; Eye disorder therapies; Nerve growth factors; Neuroprotectants; Proteins
  • Mechanism of Action Nerve growth factor receptor agonists; Neuron stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Keratitis; Retinitis pigmentosa
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Keratitis
  • Phase III Dry eyes
  • Phase II Cerebral palsy; Glaucoma; Ischaemic optic neuropathy; Retinitis pigmentosa
  • Phase I Eye disorders

Most Recent Events

  • 12 May 2026 Dompe Farmaceutici plans a phase III trial for Corneal injuries (Treatment-resistant) in USA (Ophthalmic, Drops) (CTIS2025-523443-35-00), (NCT07519902)
  • 20 Apr 2026 Dompe Farmaceutici plans a proof-of-concept phase IIa trial for Traumatic brain injuries in Denmark, Finland, France, Germany, Italy, Spain, Sweden, United Kingdom (Intranasal) (CTIS2025-522692-29-00)
  • 17 Apr 2026 700389093 CTP - data already present/no updates

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