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Cenegermin - Dompe Farmaceutici

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Drug Profile

Cenegermin - Dompe Farmaceutici

Alternative Names: Cenegermin-bkbj; Nerve growth factor - Anabasis/Dompe; Ophtha-NGF; Ophtha-NGF Intravitreal; Oxervate; rhNGF; Sentinel

Latest Information Update: 28 Sep 2025

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At a glance

  • Originator Anabasis Pharma
  • Developer Anabasis Pharma; Dompe Farmaceutici; Ospedale San Raffaele
  • Class Anti-inflammatories; Antiglaucomas; Eye disorder therapies; Nerve growth factors; Neuroprotectants; Proteins
  • Mechanism of Action Nerve growth factor receptor agonists; Neuron stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Keratitis; Retinitis pigmentosa
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Keratitis
  • Phase III Dry eyes
  • Phase II Glaucoma; Retinitis pigmentosa
  • Phase I Eye disorders

Most Recent Events

  • 28 Sep 2025 No recent reports of development identified for preclinical development in Glaucoma in Italy (Ophthalmic, Drops)
  • 04 Dec 2024 Dompe Farmaceutici completes a phase II trial for Dry eyes in Italy and USA (Ophthalmic) (NCT06244316)
  • 22 Jan 2024 Dompe Farmaceutici initiates a phase II trial for Dry eyes in Italy and USA (Ophthalmic) (NCT06244316)

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