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Paxalisib - Kazia Therapeutics

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Drug Profile

Paxalisib - Kazia Therapeutics

Alternative Names: G-02441729; GDC-0084; RG 7666; SIM-0395

Latest Information Update: 08 Oct 2024

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At a glance

  • Originator Genentech
  • Developer Alliance for Clinical Trials in Oncology; Dana-Farber Cancer Institute; Genentech; Global Coalition for Adaptive Research; Huntsman Cancer Institute; John Hopkins University; Kazia Therapeutics; Memorial Sloan-Kettering Cancer Center; National Cancer Institute (USA); St. Jude Childrens Research Hospital; University of California; Weill Cornell Medical College
  • Class Amines; Antineoplastics; Morpholines; Oxazines; Purines; Pyrimidines; Small molecules
  • Mechanism of Action 1 Phosphatidylinositol 3 kinase inhibitors; MTOR protein inhibitors; Proto-oncogene protein c-akt inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Rhabdoid tumour; Diffuse intrinsic pontine glioma; Glioblastoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Glioblastoma
  • Phase II Brain metastases; Glioma; Lymphoma
  • Phase I/II Cancer
  • Preclinical Malignant melanoma; Rhabdoid tumour
  • No development reported Diffuse intrinsic pontine glioma; Meningeal carcinomatosis

Most Recent Events

  • 02 Oct 2024 Efficacy and adverse event data from a phase II trial in Brain Metastases and Leptomeningeal Metastasisreleased by Kazia Therapeutics
  • 12 Sep 2024 Kazia Therapeutics in-licenses IP from QIMR Berghofer for PI3K Combination Therapies
  • 10 Jul 2024 Phase-I/II clinical trials in Cancer (Combination therapy, Second-line therapy or greater, In adolescents, In adults, In children, In infants, In neonates) in Canada, Australia (PO) (NCT06208657)

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