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Paxalisib - Kazia Therapeutics

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Drug Profile

Paxalisib - Kazia Therapeutics

Alternative Names: G-02441729; GDC-0084; RG 7666; SIM-0395

Latest Information Update: 28 Mar 2024

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At a glance

  • Originator Genentech
  • Developer Alliance for Clinical Trials in Oncology; Dana-Farber Cancer Institute; Genentech; Global Coalition for Adaptive Research; Huntsman Cancer Institute; John Hopkins University; Kazia Therapeutics; Memorial Sloan-Kettering Cancer Center; National Cancer Institute (USA); St. Jude Childrens Research Hospital; University of California; Weill Cornell Medical College
  • Class Amines; Antineoplastics; Morpholines; Oxazines; Purines; Pyrimidines; Small molecules
  • Mechanism of Action 1 Phosphatidylinositol 3 kinase inhibitors; MTOR protein inhibitors; Proto oncogene protein c-akt inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Rhabdoid tumour; Glioblastoma; Diffuse intrinsic pontine glioma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Glioblastoma
  • Phase II Brain metastases; Glioma; Lymphoma
  • Phase I Diffuse intrinsic pontine glioma; Meningeal carcinomatosis
  • Preclinical Malignant melanoma; Rhabdoid tumour

Most Recent Events

  • 21 Mar 2024 Paxalisib licensed to SoVarGen Worldwide excluding China, Hong Kong, Macau, Taiwan
  • 21 Mar 2024 Kazia Therapeutics in collaboration with SoVarGen plans a phase II trial for Partial epilepsies and Tuberous sclerosis in the latter half of 2024
  • 13 Mar 2024 Pacific Pediatric Neuro-Oncology Consortium plans a clincal trial for Rhabdoid tumour (atypical teratoid) (Combination therapy, Second-line therapy or greater)
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