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Savolitinib - AstraZeneca/HUTCHMED

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Drug Profile

Savolitinib - AstraZeneca/HUTCHMED

Alternative Names: AZD-6094; HMP-504; HMPL-504; Orpathys; Volitinib; Voressa

Latest Information Update: 29 Aug 2025

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At a glance

  • Originator Hutchison MediPharma
  • Developer AstraZeneca; Hutchison MediPharma; HUTCHMED; National Cancer Institute (USA); Samsung Medical Center
  • Class Antineoplastics; Imidazoles; Pyrazines; Pyrazoles; Pyridines; Small molecules; Triazoles
  • Mechanism of Action Proto-oncogene protein c-met inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • Phase III Renal cell carcinoma
  • Phase II Colorectal cancer; Gastric cancer; Oesophageal cancer; Prostate cancer
  • No development reported CNS cancer; Solid tumours

Most Recent Events

  • 20 Aug 2025 HUTCHMED completes enrolment in a phase-III trial in Non-small cell lung cancer (Combination therapy, Late-stage disease, Metastatic disease, In adults, First-line therapy) in China (PO) (NCT05009836)
  • 30 Jun 2025 Registered for Non-small cell lung cancer (Second-line therapy or greater, Metastatic disease, Combination therapy, Late-stage disease) in China (PO)
  • 02 Jun 2025 Efficacy and adverse event data from a phase III SACHI trial in Non-small cell lung cancer released by HUTCHMED

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