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Savolitinib - AstraZeneca/HUTCHMED

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Drug Profile

Savolitinib - AstraZeneca/HUTCHMED

Alternative Names: AZD-6094; HMP-504; HMPL-504; Orpathys; Volitinib; Voressa

Latest Information Update: 02 Aug 2024

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At a glance

  • Originator Hutchison MediPharma
  • Developer AstraZeneca; Hutchison MediPharma; HUTCHMED; National Cancer Institute (USA); Samsung Medical Center
  • Class Antineoplastics; Imidazoles; Pyrazines; Pyrazoles; Pyridines; Small molecules; Triazoles
  • Mechanism of Action Proto-oncogene protein c-met inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • Phase III Renal cell carcinoma
  • Phase II Colorectal cancer; Gastric cancer; Oesophageal cancer; Prostate cancer
  • No development reported CNS cancer; Solid tumours

Most Recent Events

  • 31 Jul 2024 Preregistration for Non-small cell lung cancer (First-line therapy, Late-stage disease, Metastatic disease) in China (PO)
  • 31 Jul 2024 HUTCHMED announces intention to submit NDA to US FDA for Non-small cell lung cancer in the US, at year end 2024
  • 24 Jun 2024 AstraZeneca completes a phase I trial (In volunteers) in Sweden (PO) (NCT06348355, EudraCT2023-508334-34-00)

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