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Savolitinib - AstraZeneca/HUTCHMED

Drug Profile

Savolitinib - AstraZeneca/HUTCHMED

Alternative Names: AZD-6094; HMP-504; HMPL-504; Orpathys; Volitinib; Voressa

Latest Information Update: 10 Apr 2024

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At a glance

  • Originator Hutchison MediPharma
  • Developer AstraZeneca; Hutchison MediPharma; HUTCHMED; National Cancer Institute (USA); Samsung Medical Center
  • Class Antineoplastics; Imidazoles; Pyrazines; Pyrazoles; Pyridines; Small molecules; Triazoles
  • Mechanism of Action Proto-oncogene protein c-met inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • Phase III Renal cell carcinoma
  • Phase II Colorectal cancer; Gastric cancer; Oesophageal cancer; Prostate cancer
  • No development reported CNS cancer; Solid tumours

Most Recent Events

  • 10 Apr 2024 AstraZeneca plans a phase I trial in Healthy volunteers (In adults) in Sweden (PO) in April 2024 (NCT06348355) (EudraCT2023-508334-34-00)
  • 05 Apr 2024 AstraZeneca terminates a phase II trial for Non-small cell lung cancer (Combination therapy, Late-stage disease, Metastatic disease) in USA, India, Argentina, Taiwan, Thailand, Vietnam due to an additional ongoing SAVANNAH trial prior to April 2024 (PO) (NCT04606771)
  • 28 Mar 2024 National Medical Products Administration (NMPA) accepts the supplemental New Drug Application for savolitinib for Non-small cell lung cancer for review
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