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Research programme: histone methyltransferase inhibitors - Epizyme

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Drug Profile

Research programme: histone methyltransferase inhibitors - Epizyme

Alternative Names: CARM1 inhibitors; coactivator-associated arginine methyltransferase 1 inhibitors; EPZ 020411; HMT 2; HMT 3; HMT inhibitors; PRMT1 inhibitors; PRMT3 inhibitors; PRMT6 inhibitors; PRMT8 inhibitors; Protein arginine methyltransferase 1 inhibitors; Protein arginine methyltransferase 3 inhibitors; Protein arginine methyltransferase 6 inhibitors; Protein arginine methyltransferase 8 inhibitors

Latest Information Update: 28 Oct 2024

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At a glance

  • Originator Epizyme
  • Developer Celgene International SARL; Epizyme
  • Class Antineoplastics; Pyrazoles
  • Mechanism of Action Histone methyltransferase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • No development reported Haematological malignancies; Solid tumours

Most Recent Events

  • 28 Oct 2024 No recent reports of development identified for preclinical development in Haematological-malignancies in USA
  • 28 Oct 2024 No recent reports of development identified for preclinical development in Solid-tumours in USA (Parenteral)
  • 14 Oct 2022 Research programme: histone methyltransferase inhibitors is still in preclinical trials for Haematological malignancies in USA (Epizyme pipeline, October 2022)

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