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CBL 137

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Drug Profile

CBL 137

Alternative Names: CBL-0137; CBLC-137; Curaxin CBL0137

Latest Information Update: 02 Apr 2024

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At a glance

  • Originator Cleveland BioLabs
  • Developer Incuron; National Cancer Institute (USA); Roswell Park Cancer Institute; Statera BioPharma
  • Class Antineoplastics; Carbazoles; Small molecules
  • Mechanism of Action Apoptosis stimulants; DNA intercalators; NF-kappa B inhibitors; SSRP1 protein inhibitors; Tumour suppressor protein p53 stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Diffuse intrinsic pontine glioma; Lymphoma; Osteosarcoma; Solid tumours
  • No development reported Haematological malignancies; Malignant melanoma; Neuroblastoma; Sarcoma

Most Recent Events

  • 25 Mar 2024 Roswell Park Cancer Institute and National Cancer Institute (NCI) terminates a phase I trial of Melanoma and Sarcoma (Recurrent disease, Late-stage disease, Advanced stage) in USA (Intra-arterial, Infusion), due to low accural (NCT03727789)
  • 28 Oct 2023 No recent reports of development identified for preclinical development in Neuroblastoma in USA (Parenteral)
  • 28 Aug 2022 No recent reports of development identified for phase-I development in Malignant-melanoma(Late-stage disease, Second-line therapy or greater) in USA (Intra-arterial)

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