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Mirvetuximab soravtansine - ImmunoGen

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Drug Profile

Mirvetuximab soravtansine - ImmunoGen

Alternative Names: Anti-FOLR1-monoclonal-antibody-maytansinoid-conjugate-IMGN-853; ELAHERE; IMGN-853; M9346A-sSPDB-DM4; M9346A-sulfo-SPDB-DM4; MIRV; Mirvetuximab soravtansine-gynx; TAK-853

Latest Information Update: 08 Sep 2025

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At a glance

  • Originator ImmunoGen
  • Developer Hangzhou Zhongmei Huadong Pharmaceutical; ImmunoGen; Takeda
  • Class Antineoplastics; Drug conjugates; Immunotoxins; Maytansinoids; Monoclonal antibodies
  • Mechanism of Action Tubulin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • Phase II Endometrial cancer; Triple negative breast cancer
  • Phase I/II Solid tumours

Most Recent Events

  • 20 Aug 2025 AbbVie plans a phase II trial for Ovarian cancer, Fallopian tube cancer and Peritoneal cancer (Late-stage disease, Combination therapy) in USA (IV) (NCT06890338)
  • 11 Jul 2025 AbbVie plans the phase II FLORENZA trial for Ovarian cancer, Fallopian tube cancer and Peritoneal cancer (Combination therapy, Late-stage disease, Second-line therapy or greater) (IV, Infusion), in September 2025 (EudraCT2025-521606-18), (NCT07059845)
  • 28 May 2025 AbbVie initiates a phase III trial in Ovarian cancer, Fallopian tube cancer, and Peritoneal cancer (Late-stage disease, Monotherapy, Second-line therapy or greater) (IV) in February 2025 (NCT06682988)

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