Mirvetuximab soravtansine - ImmunoGen

Drug Profile

Mirvetuximab soravtansine - ImmunoGen

Alternative Names: Anti-FOLR1-monoclonal-antibody-maytansinoid-conjugate-IMGN-853; IMGN-853; M9346A-sSPDB-DM4; M9346A-sulfo-SPDB-DM4

Latest Information Update: 28 Mar 2018

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At a glance

  • Originator ImmunoGen
  • Developer ImmunoGen; National Comprehensive Cancer Network
  • Class Antineoplastics; Drug conjugates; Immunoconjugates; Maytansinoids; Monoclonal antibodies
  • Mechanism of Action Folate receptor 1 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • Phase II Breast cancer
  • Phase I/II Endometrial cancer
  • Phase I Solid tumours

Most Recent Events

  • 24 Mar 2018 Interim efficacy and adverse events data from a phase Ib/II FORWARD II trial in Ovarian cancer released by ImmunoGen
  • 05 Jun 2017 Phase-II clinical trials in Breast cancer (Monotherapy, Newly diagnosed, Second-line therapy or greater, Metastatic disease) in USA (IV) (NCT03106077)
  • 02 Jun 2017 Additional efficacy data from a phase I trial in Ovarian cancer presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
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