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Trifarotene - Galderma/Mayne Pharma

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Drug Profile

Trifarotene - Galderma/Mayne Pharma

Alternative Names: AKLIEF; CD-5789

Latest Information Update: 29 Sep 2025

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At a glance

  • Originator Galderma
  • Developer Galderma; Mayne Pharma Group
  • Class Antiacnes; Antineoplastics; Benzoic acids; Keratolytics; Pyrrolidines; Retinoids; Skin disorder therapies; Small molecules
  • Mechanism of Action Retinoic acid receptor gamma agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ichthyosis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Acne vulgaris
  • Phase II Ichthyosis
  • No development reported Cutaneous T-cell lymphoma

Most Recent Events

  • 22 Sep 2025 Galderma plans a phase III AKLIEF trial for Acne vulgaris (In children, In adolescents, In adults, In the elederly) (Topical) (NCT07186413)
  • 13 Sep 2021 Mayne Pharma Group terminates a phase II trial in Ichthyosis (In adolescents, In adults, In the elderly) in Australia, Canada, France, Germany, Israel, Ukraine, Spain, United Kingdom and USA, due to futile outcome (Topical) (EudraCT2018-003272-12) (NCT03738800)
  • 18 Jan 2021 Registered for Acne vulgaris (In adolescents, In children, In adults) in Australia (Topical, Cream)

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