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TAS 114

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Drug Profile

TAS 114

Alternative Names: TAS-114

Latest Information Update: 25 Feb 2021

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At a glance

  • Originator Taiho Pharmaceutical
  • Developer National Cancer Center Hospital East; Taiho Pharmaceutical
  • Class Antineoplastics
  • Mechanism of Action Dihydropyrimidine dehydrogenase inhibitors; DUTP pyrophosphatase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Gastric cancer; Non-small cell lung cancer
  • No development reported Solid tumours

Most Recent Events

  • 25 Feb 2021 TAS 114 is still in phase II development for Non-small cell lung cancer in USA, Japan and EU (Taiho Pharmaceutical pipeline, February 2021)
  • 27 Sep 2019 Safety and efficacy data from a phase II trial in advanced Gastric cancer presented at the 44th European Society for Medical Oncology Congress (ESMO-2019)
  • 10 Jan 2019 National Cancer Center Hospital East and Taiho Pharmaceuticals completes a phase II trial in Gastric cancer (Combination therapy, Late-stage disease, Second-line therapy or greater, Inoperable/Unresectable, Metastatic disease, Recurrent) in Japan (PO) (UMIN000028329) (700288577.

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