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Alternative Names:
Ensacove; Ensartinib Hydrochloride; X-396
Latest Information Update: 04 Jan 2023
Price :
$50
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At a glance
Originator
Xcovery
Developer
AstraZeneca; Betta Pharmaceuticals Co Ltd; Cancer Research Institute; Ludwig Institute for Cancer Research; Memorial Sloan-Kettering Cancer Center; National Cancer Institute (USA); Xcovery Holdings
Class
Antineoplastics; Piperazines; Pyridazines; Small molecules
Mechanism of Action
Anaplastic lymphoma kinase inhibitors; EphA2 receptor antagonists; Proto oncogene protein c met inhibitors; ROS1 protein inhibitors; TrkA receptor antagonists; TrkC receptor antagonists
Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
No
New Molecular Entity
Yes
Highest Development Phases
Marketed
Non-small cell lung cancer
Phase II
CNS cancer; Malignant melanoma; Non-Hodgkin's lymphoma; Solid tumours
Most Recent Events
30 Dec 2022
National Cancer Institute re-initiates the phase II Pediatric MATCH trial in Solid tumours, Non-Hodgkin's lymphoma and CNS cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater, In infants, In children, In adolescents, In adults) in USA and Puerto Rico (PO) (NCT03213652)
27 Dec 2022
Xcovery Holding Company plans a phase I trial for Non Small Cell Lung Cancer (In healthy volunteers) (PO) (NCT05665283; XCV-X396-ONC-103)
02 Nov 2022
National Cancer Institute suspends the phase II MATCH trial in Solid tumours, Non-Hodgkin's lymphoma and CNS cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater, In infants, In children, In adolescents, In adults) in USA and Puerto Rico due to drug supply issues (PO) (NCT03213652)
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