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Ensartinib - Betta Pharmaceuticals/Xcovery

Drug Profile

Ensartinib - Betta Pharmaceuticals/Xcovery

Alternative Names: X-396

Latest Information Update: 14 Aug 2020

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At a glance

  • Originator Xcovery
  • Developer Cancer Research Institute; Ludwig Institute for Cancer Research; MedImmune; Memorial Sloan-Kettering Cancer Center; National Cancer Institute (USA); Xcovery Holdings
  • Class Antineoplastics; Piperazines; Pyridazines; Small molecules
  • Mechanism of Action Anaplastic lymphoma kinase inhibitors; EphA2 receptor antagonists; Proto oncogene protein c met inhibitors; ROS1 protein inhibitors; TrkA receptor antagonists; TrkC receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Non-small cell lung cancer
  • Phase II CNS cancer; Malignant melanoma; Non-Hodgkin's lymphoma; Solid tumours

Most Recent Events

  • 08 Aug 2020 Efficacy and adverse events data from phase III eXalt3 trial in Non-small cell lung cancer released by Xcovery
  • 22 Jun 2020 Updated efficacy, safety and pharmacokinetics data from a phase I trial in Non-small cell lung cancer presented at the 111th Annual Meeting of the American Association for Cancer Research (AACR-2020)
  • 01 May 2020 National Cancer Institute re-initiates phase II clinical trial in Solid tumours (Late-stage disease, Metastatic disease, Second-line therapy or greater, In infants, In children, In adolescents, In adults) in USA and Puerto Rico (PO) (NCT03213652)
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