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Ensartinib - Betta Pharmaceuticals/Xcovery

Drug Profile

Ensartinib - Betta Pharmaceuticals/Xcovery

Alternative Names: X-396

Latest Information Update: 19 Feb 2020

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At a glance

  • Originator Xcovery
  • Developer Cancer Research Institute; Ludwig Institute for Cancer Research; MedImmune; Memorial Sloan-Kettering Cancer Center; National Cancer Institute (USA); Xcovery Holdings
  • Class Antineoplastics; Piperazines; Pyridazines; Small molecules
  • Mechanism of Action Anaplastic lymphoma kinase inhibitors; EphA2 receptor antagonists; Proto oncogene protein c met inhibitors; ROS1 protein inhibitors; TrkA receptor antagonists; TrkC receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Non-small cell lung cancer
  • Phase II CNS cancer; Malignant melanoma; Non-Hodgkin's lymphoma; Solid tumours

Most Recent Events

  • 07 Feb 2020 National Cancer Institute suspends phase II clinical trials in Solid tumours (Late-stage disease, Metastatic disease, Second-line therapy or greater, In infants, In children, In adolescents, In adults) in USA (PO) due to scheduled interim monitoring (NCT03213652)
  • 31 Oct 2019 Xcovery initiates an expanded access programme for Non-small cell lung cancer (Second-line therapy or greater) in USA (PO) (NCT04146571)
  • 28 Dec 2018 Betta Pharmaceuticals initiates enrolment in a phase I trial for Non-small cell lung cancer (In volunteers) in China (PO) (NCT03804541)
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