Drug Profile

Simufilam - Cassava Sciences

Alternative Names: C0105; C0105M; Filora; PTI-125; PTI-910; Simufilam hydrochloride; Sumifilam - Cassava Sciences

Latest Information Update: 04 Jul 2025

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At a glance

Originator Pain Therapeutics
Developer Cassava Sciences
Class Antidementias; Ketones; Small molecules
Mechanism of Action Microfilament protein modulators

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase III Alzheimer's disease
Preclinical Seizures

Most Recent Events

30 Jun 2025 Pharmacodynamics and adverse event data from a preclinical trial in Seizers released by Cassava Sciences
08 May 2025 Preclinical trials in Seizures in USA (PO)
08 May 2025 Cassava Sciences plans a clinical trial for Seizures in first half of 2026

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